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Semaglutide use in patients with diabetes was associated with an increased risk of nonarteritic anterior ischemic optic neuropathy (NAION) at 2, 3, and 4 years. https: ja.ma 4iZkMeV Twoyear effect of semaglutide 2.4 mg on control of eating in adults with overweight obesity: STEP 5 Wharton 2023 Obesity Wiley Online Library Side Effects of Weight Loss Drug Semaglutide: Bloating, Diarrhea Business Insider Subcutaneous Semaglutide during Breastfeeding: Infant Safety Regarding Drug Transfer into Human Milk Weight Loss Houston Semiglutide Friendswood Serendipity A spectroscopic and molecular dynamics study on the aggregation process of a long acting lipidated therapeutic peptide: the case of semaglutide Soft Matter (RSC Publishing) DOI:10.1039 D0SM01011A
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Best in 7 days
Best in 7 days
Best in 7 days
Best in 7 days
4.9 ★★★★★
Based on 1629 reviews
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Product Reviews
★★★★★ 5
Fantastic for rosacea, PD, atopic dermatitis, dry skin
I’ve been using this for close to a year and it is amazing for my super sensitive and dry skin. I have perioral dermatitis, atopic dermatitis, and rosacea and live in Minnesota with bitter cold and the heater running over half the year. Cicalfate cream doesn’t flare any of these and it helps reduce redness and completely resolves dry skin. I use about a pea size amount AM and PM,, apply to dry skin, massage in, then mist with the Avene thermal water spray. Although the cream is thick, the slight white cast absorbs within a few minutes. I do not wear foundation so I don’t know how this affects it.it doesn’t burn my eyes and I’m a contact lens wearer. A big tube of cream lasts me the better part of a year.
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Reviewed in the United States on August 28, 2025
★★★★★ 5
Great for harsh winters
I was recommended this product by ChatGPT as an effective and safe product that my wife (who is currently nursing) can use. We have been very mindful of certain additives and chemicals in our products and this was able to meet our requirements.
Separately in the harsh winter in the northeast, this has been extremely effective in protecting the lips
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Reviewed in the United States on January 29, 2026
★★★★★ 1
Ruined by Reformulation
New formula update: They ruined this product by reformulating. Used to be so hydrating, long-lasting, and the only thing that gave me relief from eczema. Now it is somehow SO drying, oily, and all around terrible. Judging by reviews here and on their website many customers are unhappy with the change. Done with Avene.
Original five star review: This is a great all around lip balm, but if you struggle with perioral dermatitis/eczema then you NEED this. If I'm experiencing a flare, I slather on cicalfate+ at night but I can't exactly walk around with that during the day which is where this lip product comes in. It is calming, hydrating, and long-lasting. I have gone through more tubes than I can count. This was my first time ordering through amazon and I am happy to report I received authentic Avene.
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Reviewed in the United States on June 1, 2022
★★★★★ 5
It’s a God Send
I had a rash all around my lips and my lips got extremely dried out and started to peel. I used Avene Cicalfate Restorative Lip Cream and it really soothed my lips with the moisture they needed, and you don’t need to use a lot of this product. I plan on buying this again. Just wish the tube was bigger! I use other Avene products and I’m extremely happy with them.
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Reviewed in the United States on April 6, 2026
★★★★★ 5
Holy Grail Moisturizer for Rosacea
Style: Restorative Protective Cream-3.3 Fl Oz
In seeing so many negative reviews I felt compelled to weigh in as this is my favorite moisturizer. I have very dry, menopausal skin. Additionally, I have rosacea which seems to have been a nice gift from said menopause (you can only laugh, right?). It's very common for those of us in our 50's to have a compromised skin barrier and when an issue like rosacea is present, even more so. Because of all this my skin is very intolerant to most moisturizers and nearly all actives (over the last few years I've had to discontinue my retinols and chemical exfoliators). While ingredients like ALA's, petrolatum, mineral oil, parafin/bees wax, and lanolin are well tolerated and known to be quite soothing, they don't hydrate very well as they are more occlusive than moisturizing. Enter this product. Magically, it does both! It's marketed as a protective cream, which again implies occlusive, but it penetrates like no other. Gone is the tight, dry feeling that persisted even when I had a heavy layer of product on my skin (my previous moisturizer was Eucerin Original Healing Cream -- which still has its uses -- because it was the only thing I could put on my skin outside of squalane oil during a flare).
Now, no topical can cure rosacea. However, the right product can calm the skin, repair the damaged lipid barrier, and improve its appearance. This moisturizer does just that and it's become my holy grail. Since starting this I've also added in the Cicalfate Serum which has only aided in repairing my skin. Another Avene product that works great for me is the XeraCalm Balm which helps with itching. I use all three of these daily and they've really helped fix the secondary issues that come with rosacea.
As for the complaints about it being greasy or too heavy. I can see this not working for people with normal or oily skin (or perhaps only in moderation). But my skin loves the heavier weight and because one of the ways I soothe a flare is to keep a tiny mister bottle on hand and repeatedly spray my face so I have to guard against the drying effects of evaporation. These products are so lipid heavy that I can wet my face all day long without worrying about that, though I do reapply throughout the day.
As for the watery consistency issue, I haven't had that problem but it does caution on the packaging not to expose the product to temperatures below 41 degrees F (5 C). I suspect that if it gets too cold either because of the weather or because of whatever warehouse it sat in during transit it will separate. Maybe open the package and before squeezing some out look to see if it has split and then shake it up/message the tube.
So, if you have skin like mine don't hesitate to try this product. I'm leaving this absurdly long review for my struggling brothers and sisters out there with rosacea in hopes that it provides some relief! Happy moisturizing, internet strangers. ;)
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Reviewed in the United States on July 18, 2025
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